Chromatographic process for the production of highly purified polyunsaturated fatty acids

摘要

A process is provided for recovering a first polyunsaturated fatty acid (PUFA) from a feed mixture including at least one additional fatty acid (e.g., a second fatty acid (FA)). The process optionally comprises:
performing a main step of chromatographic separation using an aqueous organic eluent and collecting a first stream of eluent enriched in the first PUFA and a second stream of eluent enriched in the second FA;subjecting the second stream of eluent to a partial concentration step to obtain a concentrated portion including the second FA, and a depleted portion comprising eluent, but depleted of the second FA.;The process also includes:
at least partially recycling the depleted portion for use in the main step of chromatographic separation.

主权项

1. A process for recovering a first polyunsaturated fatty acid from a feed mixture that comprises the first polyunsaturated fatty acid and at least a second fatty acid in addition to the first polyunsaturated fatty acid, the process comprising:
forming a final product having the first polyunsaturated fatty acid at greater than or equal to about 90% by weight and less than or equal to about 2% by weight of the second fatty acid, wherein the forming comprises: performing a main step of chromatographic separation using an aqueous organic eluent and thereby collecting a first stream of eluent enriched in the first polyunsaturated fatty acid and a second stream of eluent enriched in the second fatty acid; subjecting the second stream of eluent to a partial concentration step so as to obtain a concentrated portion of the second stream comprising the second fatty acid and a depleted portion of the second stream comprising the eluent, but depleted of the second fatty acid; and at least partially recycling the depleted portion of the second stream to use it in the main step of chromatographic separation.