| 摘要 |
NEW MATERIAL:A compound shown by the formula I (R is isopropyl, isobutyl, or sec-butyl). EXAMPLE:1, 2, 3, 4-Tetrahydro-2,4-dioxopyrimidin-5-carboxylic acid isopropyl ester. USE:An intermediate for a drug having strong multiplication inhibitory action on various tumor cells of mammals, life prolonging effects on leukemia and antiviral effects. PREPARATION:A carboxlic acid corresponding to a compound shown by the formula I is treated with a chlorinating agent in dimethylformamide (DMF) to give a corresponding carboxylic acid chloride-DMF.(1/2)HCl complex, which is reacted with a compound shown by the formula R-OH, to give a compound shown by the formula I. This compound is fluorinated in the presence of water, etc., to give a compound shown by the formula II (R1 is OH which may be optionally etheriifed) useful as the above-mentioned drug. |
