| 发明名称 |
Novel organic trithio oxides and method for the preparation thereof. |
| 摘要 |
<p>This invention relates to novel organic trithio oxides of the formula: R<Sup>1</Sup>-X-R-X<Sup>1</Sup>-R<Sup>1</Sup> wherein R is selected from
<Chemistry id="chema01" num="0001"><Image id="ia01" he="22" wi="84" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>X is selected from
<Chemistry id="chema02" num="0002"><Image id="ia02" he="9" wi="26" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>X' is selected from -S-S-,
<Chemistry id="chema03" num="0003"><Image id="ia03" he="11" wi="41" file="IMGA0003.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>and each R' is independently selected from carboxyalkyl, alkoxy, alkylthio, amino, alkylamino and acyl substituted and unsubstituted lower alkyl, lower alkenyl, lower alkynyl, phenyl and lower alkylphenyl; provided when R is
<Chemistry id="chema04" num="0004"><Image id="ia04" he="9" wi="85" file="IMGA0004.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>then R<Sup>1</Sup> is not in both instances -CH<Sub>2</Sub>CH=CH<Sub>2</Sub>.</p><p>This invention also relates to a method of preparing the above-identified compounds by heating and further oxidiz- ing various oxides of organic disulfides and to antithrombotic uses of the compounds.</p> |
| 申请公布号 |
EP0185324(A2) |
申请公布日期 |
1986.06.25 |
| 申请号 |
EP19850115902 |
申请日期 |
1985.12.13 |
| 申请人 |
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK |
发明人 |
BLOCK, ERIC, DR.;AHMAD, SALEEM |
| 分类号 |
A61K31/095;A61K31/105;C07C323/65;C07C381/00;C07C381/04;(IPC1-7):C07C147/02;C07C147/14;A61K31/10 |
主分类号 |
A61K31/095 |
| 代理机构 |
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