| 摘要 |
NEW MATERIAL:A compound shown by the formula I (R1 is 1-12C alkyl, or hydroxy-substituted lower alkyl; R2 and R3 are lower alkyl, or phenyl) and its salt. EXAMPLE:8-Methyl-6-phenyl-2-sec-butyltriazolo[4,3-b]pyridazin-3-one. USE:A cardiac, or a drug for bronchiectasis. PREPARATION:A compound shown by the formula II is reacted with an alkyl halide in an inert solvent such as DMF, benzene, etc., in the presence of an alkali (e.g., sodium carbonate, NaOH, or pyridine) at room temperature - the boiling point of the solvent to give a compound shown by the formula I where R1 is alkyl, or a compound shown by the formula II is reacted with an alkylene carbonate in an inert solvent such as DMF, benzene, etc., in the presence of a catalytic amount of an alkali at 100-130 deg.C, to give a compound shown by the formula I where R1 is hydroxy-substituted lower alkyl.
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