| 摘要 |
A compound (I): <CHEM> in which A is C-CN or N, R is alkyl, aralkyl, (C3 or more) alkenyl, whose double bond is not attached to the carbon atom linked to the benzene or pyridine ring, or alkynyl, is prepared by treating a compound (II): <CHEM> with 1 to 2 mols/mol of a Grignard reagent, RMgX. Treatment of (I), in which A is C-CN, with further Grignard reagent gives a Grignard compound (III): <CHEM> in which Q is CN or halo. Compound (III) can be obtained by a single stage process from tetrafluorotherephthalonitrile using more than 2 mols, preferably 3 mols, of Grignard reagent and may be used to form a compound (IV): <CHEM> in which R<2> is hydrogen, alkyl, alkenyl, hydroxy, carboxy, a carboxylic ester, formyl, hydroxyalkyl, alkoxyalkyl, or <CHEM> in which R<3> and R<4>, which may be the same or different, are hydrogen or alkyl, by a Grignard reaction conventionally used to transform a Grignard compound ArMgX<2>, in which Ar is aryl and X<2> is halo, into a compound Ar-R<2>. Compounds (I), (III) and (IV) are useful intermediates in the synthesis of pesticidal compounds. |
