发明名称 |
Process for the manufacture of chiral azetidinones. |
摘要 |
<p>Manufacture of chiral azetidinones of the general formula …<CHEM>… wherein R is an amino protecting group and M +/ &cir& is a cation, starting from L-ascorbic acid. Several alternatives lead, over a number of novel intermediates, to a novel intermediate of the formula …<CHEM>… wherein R and M +/ &cir& are as above and R<9>O- is a leaving group, which is treated with an alkali metal carbonate or bicarbonate, whereupon the compound of formula II is recovered from the reaction mixture. …<??>The compounds of formula II are useful for preparing the new sulfazecin related antibiotic compound of the formula …<CHEM>… …<??>This new antibiotic is similar in activity to the antibiotic azthreonam and useful in treating infectious diseases caused by gram negative microorganisms, particularly P. aeruginosa.</p> |
申请公布号 |
EP0111326(A1) |
申请公布日期 |
1984.06.20 |
申请号 |
EP19830112377 |
申请日期 |
1983.12.08 |
申请人 |
F. HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT |
发明人 |
WEI, CHUNG-CHEN;WEIGELE, MANFRED |
分类号 |
C07C237/06;C07C237/22;C07D205/08;C07D205/085;C07D307/62;C07D317/30;C07D407/04;C07D417/12;(IPC1-7):07D205/08;07D317/30;07C125/065;07C143/86;07C143/68 |
主分类号 |
C07C237/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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