FREMGANGSMAATE FOR FREMSTILLING AV D-(-)-FENYLGYCINFORBINDELSER VED ENZYMATISK HYDANTOINHYDROLYSE

摘要

1506067 Preparation of D-carbamoylamino acids; the corresponding D-amino acids SNAMPROGETTI SpA 11 May 1976 [12 May 1975] 19444/76 Addition to 1452591 Heading C2C The invention comprises a process for producing a D-carbamoyl amino acid of Formula I wherein X is H, halogen, OH, NO 2 , alkoxy, carboxy or a hydrocarbon radical by enzymatic hydrolysis of a racemic hydantoin of Formula II in the presence of, as enzyme, hydropyrimidine hydrolase obtained from calf liver at a pH in the range 8 to 9, and optionally hydrolysing the product by boiling in water to obtain the free amino acid of Formula III