发明名称 |
Ester derivatives of alkoxybenzoyldeoxyfluorouridine |
摘要 |
New ester derivatives of alkoxybenzoyldeoxyfluorouridine of the general formula <IMAGE> wherein R stands for an alkoxy group having 1 to 4 carbon atoms, m for 1 or 2, and n for 3 or 4 with the proviso that when m is 2, the adjacent two R's may be combined to form an alkylenedioxy group as a whole. These derivatives are prepared by acylating a 2'-deoxy-3',5'-di-O-alkylcarbonyl-5-fluorouridine with corresponding benzoyl halides and are useful as active ingredients for anti-tumor agents, especially for oral administration.
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申请公布号 |
US4425335(A) |
申请公布日期 |
1984.01.10 |
申请号 |
US19810291809 |
申请日期 |
1981.08.10 |
申请人 |
FUNAI KAKUHIN KOGYO KABUSHIKI KAISHA |
发明人 |
FUJII, SETSURO;YASUI, BOMPEI;NAKAMURA, MITSUO;HIROHASHI, MITSURU;MIYAMOTO, TOMOHISA;ANDO, KAZUKO;HASHIMOTO, IWAO;UMEDA, NAOKI;KAWASAKI, MASAHIRO |
分类号 |
C07H19/073;A61K31/70;A61K31/7042;A61K31/7052;A61K31/7064;A61K31/7072;A61P35/00;C07H19/06;(IPC1-7):A61K31/70;C07H19/08 |
主分类号 |
C07H19/073 |
代理机构 |
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