Glycerol derivatives, process for preparing same and pharmaceutical composition containing same.

摘要

Glycerol derivatives of the general formula: <CHEM> in which A, B, D, R<1>, R<2>, R<3> and R<4> have the meaning given in the specification, possess antagonistic effect on PAF, hypotensive effect like PAF, inhibitory effect on phospholipase and inhibitory effect on growth of tumour cell or induction of differentiation, and are, therefore, useful as a platelet aggregation inhibitor, anti-asthmatic agent, antiallergic agent, anti-inflammatory agent, hypotensive agent and anti-tumour agent for mammals. Disclosed are also methods for preparing the novel compounds.