| 摘要 |
PURPOSE:To prepare a novel carcinostatic substance NC-42 substance, by subjecting preneocarzinostatin to S-carboxymethylation, followed by treating it with protease, etc. CONSTITUTION:Preneocarzinostatin is subjected to S-carboxymethylation by a conventional procedure to give S-carboxymethylated preneocarzinostatin, which is treated with protease such as trypsin, etc., a reaction product is treated with NCS-chromophore, and a carcinostatic substance NC-42 substance is isolated and purified from a reaction solution by using one or a combination of ion chromatography, dialysis, ultrafiltration, gel filtration, etc. |
