| 摘要 |
Cephalosporins (I; R = II or III; Y = H, o-hydroxy, p-hydroxy; X = H, amino; R1 = 1,3,4-thiadiazol-2-yl, 5-methyl-1,3,4-thiadiazol, etc.; M = H, alkali metal) were prepd. thus, 5.2 g Na 7-≮D-α-butoxycarbonylamino-α-(p-hydroxyphenyl)acetamido cephalosporanic acid in 100 ml potassium phosphate buffer soln. (pH = 6.4) was reacted with MeOH soin. contg.1.3 g Na 5-mercapto-1,2,3-triazole and 8.8 g 1,4,7.10,13-pentaoxacyclopentadecane at 45≦̸C for 3 hr to give 3.4 g 7-≮D-α-amino-α-(P-hyderoxyphenyl)acetamido≉-3-(1,2,3-triazol-5-ylthio methyl)-Δ3 cephem-4-carboxylic acid.
|
