4-(1-Imidazolylmethyl)cinnamic acid hydrochloride monohydrate, method of preparation thereof, and pharmaceutical composition containing same.

摘要

4-(1-Imidazolylmethyl)cinnamic acid hydrochloride monohydrate of the formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="9" wi="81" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>and pharmaceutical compositions containing such compound.

The imidazole derivative above has a strong and specific inhibitory effect on thromboxane synthetase from human or bovine platelet microsomes, is useful as a therapeutical agent for inflammation. hypertension, thrombus, cerebral apoplexy, and asthma, and is non-hygroscopic.