发明名称 |
2,6-C-DIMETHYLTYROSINE 1-D-AMINOZUUR 2-EPSILON-AMINOCAPRONZUUR EN GAMMA-AMINOBOTERZUUR 5-DERIVATEN VAN METHIONINE-ENKEFALINE. |
摘要 |
An enkephalin derivative represented by the formula (+/-) H-2,6-C-diMeTyr-(D)X-Gly-Phe-N(CH2)mCOOR wherein: X is methionine, alanine or nor-leucine; m is 3 or 5; and R is selected from the group consisting of hydrogen, lower alkyl or -NR2R3 wherein R2 and R3 are the same or different members of the group consisting of hydrogen and lower alkyl, wherein the (+/-) refers to the compound shown, its mirror image or a mixture of racemates; or the pharmaceutically acceptable salts thereof. The compounds are useful as analgesic agents. |
申请公布号 |
NL8104976(A) |
申请公布日期 |
1982.06.01 |
申请号 |
NL19810004976 |
申请日期 |
1981.11.03 |
申请人 |
G.D. SEARLE & CO. TE SKOKIE, ILLINOIS, VER. ST. V. AM. |
发明人 |
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分类号 |
C07K14/655;A61K38/00;A61K38/22;A61P25/04;C07K7/02;C07K14/575;C07K14/70;(IPC1-7):07C103/52;61K37/02 |
主分类号 |
C07K14/655 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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