THERAPEUTICALLY ACTIVE SUBSTITUTED DIBENZYL ETHERS

摘要

Therapeutically Active Substituted Dibenzyl Ethers There are provided 2,4-dichloro-4'-phenyl-.alpha.-(N-imidazolyl--methyl)-dibenzyl ether, 2,4-dichloro-4'-phenylthio-.alpha.--(N-imidazolyl-methyl)-dubenzyl ether and pharmaceutically acceptable acid addition salts thereof. These compounds show activity against some fungi, yeasts and gram positive aerobic and anaerobic bacteria. The new compounds can be prepared by condensing 1-(2',4'--dichlorophenyl)-2-(N-imidazolyl-methyl)-ethanol with 4-chloromethyl-biphenyl), 4-bromomethyl-biphenyl, 1-phenylthio-4-chloromethyl-benzene or 1-phenylthio-4--bromomethyl-benzene in a solvent, most preferably dimethylsulphoxide.