发明名称 |
CORTICOTROPIN RELEASING FACTOR RECEPTOR 1-DEFICIENT MICE |
摘要 |
Signaling pathways dependent on members of the corticotropin releasing factor (CRF) gene family exert pleiotropic effects within both the brain and peripheral tissues. Two biochemically and pharmacologically distinct corticotropin releasing factor receptor subtypes (corticotropin releasing factor receptor-1 and corticotropin releasing factor receptor-2) have been described. To study the developmental and physiological role of the specific receptor subtypes, a strain of mice null for the corticotropin releasing factor receptor-1 gene has been generated. This genetically engineered strain of mice suggest that corticotropin releasing factor receptor-1 is obligatory both in development and function of the hypothalamic-pituitary-adrenal axis and in mediating behavioral changes associated with anxiety and locomotor activity rhythms.
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申请公布号 |
WO9950657(A1) |
申请公布日期 |
1999.10.07 |
申请号 |
WO1999US06967 |
申请日期 |
1999.03.30 |
申请人 |
RESEARCH DEVELOPMENT FOUNDATION |
发明人 |
LEE, KUO-FEN;VALE, WYLIE |
分类号 |
A01K67/027;A61K31/56;A61K31/573;A61P11/00;C07K2/00;C07K14/72;C12N15/00;C12N15/09;C12N15/85;G01N33/15;G01N33/50;G01N33/53;(IPC1-7):G01N33/00;A61K48/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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