发明名称 Cephalosporins having an alpha -acylaminoacetic acid side chain
摘要 Compounds of the formula <IMAGE> wherein R1 denotes optionally substituted phenyl, thienyl, furyl or 1,4-cyclohexadienyl, R2 represents a free carboxyl group or an esterified carboxyl group which can be split physiologically, R3 represents hydrogen, lower alkoxy or an optionally substituted methyl group and B represents an optionally substitued six-membered ring with 1 to 3 ring nitrogen atoms, which is bonded to the carbonyl group -C(=O)- by one of its carbon atoms, the nitrogen atoms of a monocyclic six-membered ring having 2 nitrogen atoms being either adjacent or separated by two ring carbon atoms, and the salts of such compounds which have a salt-forming group, including the inner salts, for example the 7 beta -[D(-)- alpha -(3,5-Dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carboxamido)-phenylace tamido]-cephalosporanic acid, have antibiotic activity.
申请公布号 US4265892(A) 申请公布日期 1981.05.05
申请号 US19790011359 申请日期 1979.02.12
申请人 CIBA-GEIGY CORPORATION 发明人 KOCSIS, KAROLY;PETER, HEINRICH;BICKEL, HANS
分类号 A23K1/17;C07D285/12;C07D285/135;C07D501/20;(IPC1-7):A61K31/54 主分类号 A23K1/17
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