6-Desoxy- und 4,6-Didesoxy-dibekacin sowie deren 1-N(L-4-Amino-2-hydroxybutyryl)-Derivate. Verfahren zu Ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

摘要

New compounds, 6''-deoxydibekacin, 4'', 6''-dideoxydibekacin, 1-N-(L-4-amino-2-hydroxybutyryl)-6''-deoxydibekacin and 1-N-(L-4-amino-2-hydroxybutyryl)-4'',6''-dideoxydibekacin are now produced semi-synthetically from dibekacin, i.e. 3',4'-dideoxykanamycin B. These four new compounds are each useful as an antibacterial agent. Production of 6''-deoxydibekacin or 4'',6''-dideoxydibekacin is made by removal of the 6''-hydroxyl group or by removal of the 4''- and 6''-hydroxyl groups from an amino-protected and hydroxyl-protected derivative of dibekacin. Production of 1-N-(L-4-amino-2-hydroxybutyryl)-6''-deoxydibekacin or -4'',6''-dideoxydibekacin is made by acylating the 1-amino group of 6''-deoxydibekacin or 4'',6''-dideoxydibekacin with the L-4-amino-2-hydroxybutyryl group, or alternatively by removal of the 6''-hydroxyl group or the 4''- and 6''-hydroxyl groups from a known compound, 1-N-(L-4-amino-2-hydroxybutyryl)-dibekacin.