Process for the preparation of the crystalline monohydrate of 7-[D-amino-(p-hydroxyphenyl]acetamido)-3-methyl-3-cephen-4-carboxylic acid

摘要

A novel crystalline monohydrate of 7-[D- alpha -amino- alpha -(p-hydroxyphenyl)acetamido]-3-methyl-3-cephem-4-carboxylic acid is prepared and found to be a stable useful form of the cephalosporin antibiotic especially advantageous for pharmaceutical formulations.