NOVEL ANTIBIOTIC* NANAOMYCIN E AND ITS PREPARATION

摘要

NEW MATERIAL:Nanaomycin E of the formula. USE:Antibiotic: it is active against gram-positive bacteria and fungi. Althout it is equal or inferior in antibiotic activity to Nanaomycin A and D, it is superior in acute toxicity and it is also used as the intermediate for Nanaomycin A useful as an antibiotic. PREPARATION:A mould producing Nanaomycin E that belongs to Streptomyces such as Streptomyces rosa variant notoensis FERM P-2209 is aerobically incubated in a synthetic or natural medium containing well-balanced nutritions as carbon and nitrogen sources, inotganic comound and othes usually at 20 - 40 deg.C for 1 - 2 days and produced Nanaomycin E is extracted with ethyl acetate under acidic conditions and separated and purified using silica-gel column chromatography.