| 摘要 |
1506022 1 - Acyl - 4(o - halophenyl) thiosemicarbazides ELI LILLY & CO 6 March 1975 [7 March 1974] 44476/77 Divided out of 1506021 Heading C2C The invention comprises 1-acyl-4-(o-halophenyl)-3-thiosemicarbazides of the general Formula I wherein R is hydrogen, C 1 to C 11 alkyl, cyclopropyl or trifluoromethyl; R 1 is hydrogen, bromo, chloro or fluoro; R 2 and R 3 are independently hydrogen, C 1 to C 3 alkyl, C 1 to C 3 alkoxy, bromo, chloro, fluoro or trifluoromethyl provided that at least one of R 2 and R 3 is hydrogen; X is bromo, chloro or fluoro and provided that when R 1 is hydrogen, R is other than hydrogen and R 2 is hydrogen. The compounds of Formula I may be prepared by molar equivalents of an acyl hydrazine of formula NH 2 NHCOR and an o-halophenylisothiocyanate in a substantially anhydrous aprotic solvent at from 60‹ to 100‹ C. for about 24 hours. |
