发明名称 |
55*SUBSTITUTED PHENYL*OXAZOLIDINONE AND SULFUR HOMOLOGUE THEREOF PROCESS FOR PREPARING SAME AND MEDICINE CONTAINING SAME |
摘要 |
Novel 5-(subst. phenyl)-oxazolidinones and their sulphur analogs of the general formula I <IMAGE> in which the substituents are defined in Claim 1, are obtained by reacting 2-amino-1(3,4-disubst. phenyl)-ethanols with a carbonic acid derivative or a thiocarbonic acid derivative in an inert solvent while heating in the presence of a basic catalyst. The novel compounds of the general formula I possess valuable pharmacological properties. They exhibit antidopaminergic, antinociceptive and anticonvulsive effects and have a depressant action on the central nervous system and thus have a certain similarity to neuroleptic agents such as chlorpromazine or haloperidol. In addition, the novel compounds possess strong phosphodiesterase-inhibiting properties and thus affect the metabolism of cyclic nucleotides. The compounds are also suitable for treating hyperproliferative diseases and diseases associated with uncontrolled cell growth. |
申请公布号 |
JPS5382777(A) |
申请公布日期 |
1978.07.21 |
申请号 |
JP19770144922 |
申请日期 |
1977.12.02 |
申请人 |
SCHERING AG |
发明人 |
ANDOREASU FUUTO;RARUFU SHIYUMIIHIEN;BUORUFUGANKU KEERU;GERUTO PASHIERUKE;HERUMUUTO BUAHATERU;HERUBERUTO HANSU SHIYUNAIDAA;DEIITAA PARENSHIYAATO |
分类号 |
C07D277/12;A61K31/42;A61K31/421;A61K31/425;A61K31/426;A61P7/00;A61P7/02;A61P11/00;A61P17/00;A61P25/00;A61P25/02;A61P25/08;A61P25/18;A61P25/20;A61P43/00;C07D263/16;C07D263/20;C07D263/24;C07D263/26;C07D277/14;C07D277/16;C07D413/12 |
主分类号 |
C07D277/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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