| 摘要 |
<p>Prepn. of 3-(7-theophyllinyl)propanesulphonic acid (I) is by reaction of theophyllin in presence of an alkali metal hydroxide with a substd. propane of formula X CH2-CH2-CH2-Y (II) (where X is Cl, Br, I or sulphonyloxy residues of sulphonic acids; Y is as X or alkali metal sulphonate). Product (III) is reacted with an alkali metal sulphonate (when Y is not alkali metal sulphonate). (III) is then treated with an acid to give the free sulphonic acid. (I) is a cerebral and coronary vasolidator and spasmolytic. Typically 3-(7-theophyllinyl)propanesulphonic acid was prepd. by reaction of theophyllin with sodium chloropropanesulphonate at 80 degrees C, cooling to room temp., and acidifying with HCl to give crystals of the required acid.</p> |
