发明名称 |
Targeted gene delivery to cells by filamentous bacteriophage |
摘要 |
This invention provides methods specifically delivering and expressing heterologous nucleic acids in target cells. The methods generally involve providing a phage externally displaying a heterologues targeting protein (e.g., a scFv) and containing a heterologous nucleic acid; and contacting the target cell with the said phage whereby the phage is internalized into the cell and wherein the heterologous nucleic acid is transcribed, and optionally translated, within the cell. |
申请公布号 |
AU3743299(A) |
申请公布日期 |
1999.11.16 |
申请号 |
AU19990037432 |
申请日期 |
1999.04.23 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, |
发明人 |
JAMES D. MARKS;MARIE ALIX POUL;BALTAZAR BECERRIL |
分类号 |
A61K38/00;A61K47/48;C07K14/01;C07K16/28;C07K16/32;C12N15/86 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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