| 摘要 |
Oxazole derivatives (I) Y = phenyl-, benzyl- which may be subst. by up to 2 hal- or CF3 Z = -CR1R2R3 R1 = H-, C1-3 alkyl- R2 = H-, C1-3 alkyl-, C2-6 alkoxycarbonyl- R3 = CO2R4 or -CONHR5 R4 = H-, alkyl-, dialkylaminoalkyl-, benzyl-, phenyl-, R5 = H-, -OH, -NH2, dialkylaminoalkyl-, alkoxycarbonylalkyl-, carboxyalkyl-particularly aluminium 2-(4-chlorophenyl) oxazol-4-acetate. Anti-inflammatory, analgesic, antipyretic. A mixture of 2(4-chlorophenyl)-4-cyanomethyl-oxazole, dry ethanol and conc. H2SO4 is heated for 10 hours at 100 deg.C. The solution is poured into ice-water and the mixture filtered to yield solid ethyl 2-(4-chlorophenyl)oxazol-4-yl acetate. |
