Geschützte Derivate des Tryptophans, Verfahren zu deren Herstellung und deren Verwendung

摘要

Protected tryptophan derivatives which are protected on the NH group of the indole nucleus by the tert.-butyloxycarbonyl group and are protected on the alpha-amino group by the 9-fluorenylmethyloxy-carbonyl group are described. The carboxyl group of these tryptophan derivatives is in free form, in protected form, in activated form or bound as acyl group to the remaining part of a molecule, for example of a polymer material or to the amino group of another amino acid, it being possible for the other amino acid to be, for example, an amino acid of a dipeptide, of a polypeptide or of a protein structure. …The tryptophan derivatives according to the invention are advantageous specifically for carrying out synthetic processes in which electrophilic reagents are employed, for example in the preparation of dipeptides, polypeptides and proteins, in which protective groups containing sulphonyl groups are employed to protect side chains.