| 摘要 |
Use of a compound of formula I, where R1, R2 and R3 are the same or diffe rent and signify hydrogens, halogens, alkyl, alkylaryl, alkyloxy, hydroxy, n itro, amino, alkylcarbonylamino, alkylamino or dialkylamino group; R4 signif ies hydrogen, alkyl or alkylaryl group; X signifies CH2, oxygen atom or sulp hur atom; n is 1, 2 or 3, with the proviso that when n is 1, X is not CH2; a nd the individual (R)- and (S)-enantiomers or mixtures of enantiomers and ph armaceutically acceptable salts thereof; wherein the term alkyl means hydroc arbon chains, straight or branched, containing from one to six carbon atoms, optionally substituted by aryl, alkoxy, halogen, alkoxycarbonyl or hydroxyc arbonyl groups; the term aryl means a phenyl or naphthyl group, optionally s ubstituted by alkyloxy, halogen or nitro group; the term halogen means fluor ine, chlorine, bromine or iodine, in the manufacture of a medicament for the treatment of one or more of the following indications congestive heart fail ure, angina, arrhythmias, circulatory disorders such as Raynaud's Phenomenon , migraine, and anxiety disorders.
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