| 发明名称 |
Recombinant viruses coding for a glutamate decarboxylase (gad) activity |
| 摘要 |
Recombinant defective virus contg. a DNA sequence (I) encoding a protein (II) with glutamate decarboxylase (GAD) activity, is new. Also new are:(1) a virus as above where the DNA is cDNA or gDNA which is under the control of a LTR-RSV promoter (which can be expressed in the majority of nerve cells);(2) a pharmaceutical compsn. contg. the virus;(3) mammalian cells infected with this virus, and(4) implants contg. these cells and an extracellular matrix. |
| 申请公布号 |
AU2140695(A) |
申请公布日期 |
1995.10.09 |
| 申请号 |
AU19950021406 |
申请日期 |
1995.03.21 |
| 申请人 |
RHONE-POULENC RORER S.A. |
发明人 |
ALEXIS BEMELMANS;MARIE-CLAUDE GEOFFROY;PHILIPPE HORELLOU;JEAN-FRANCOIS JULIEN;JACQUES MALLET;MICHEL PERRICAUDET;JEAN-JACQUES ROBERT;EMMANUELLE VIGNE |
| 分类号 |
C12N15/09;A61K9/00;A61K31/70;A61K35/76;A61K38/00;A61K38/46;A61K47/48;A61K48/00;A61P9/00;A61P25/00;A61P25/28;C07H21/04;C12N5/10;C12N7/00;C12N9/88;C12N15/00;C12R1/91 |
主分类号 |
C12N15/09 |
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