STATISTICAL GENETICS ANALYSIS SYSTEM, STATISTICAL GENETICS ANALYSIS METHOD, AND STATISTICAL GENETICS ANALYSIS PROGRAM

摘要

An LD index computation device generates genotype data of possible multiple loci including two specific loci with a collection of multi-loci genotype data of individuals. The LD index computation device computes for each possible multiple loci including the two specific loci maximum likelihood estimates of haplotype frequencies and converts the computed maximum likelihood estimates into haplotype frequencies between two loci. The LD index computation device computes variances and confidence intervals through a plurality of different methods and converts the computed variances and the computed confidence intervals into information of two loci. The LD index computation device compares variances relating to two loci computed through the different methods and determines whether the maximum likelihood estimates fall within the confidence intervals and stores confidence intervals and corresponding two-loci haplotype frequencies in a confidence interval estimation result storage unit. The LD index computation device compares confidence intervals stored in the confidence interval estimation result storage unit for each possible multiple loci including the two specific loci to specifies a confidence interval that is to be adopted and corresponding two-loci haplotype frequencies. As a result, even when the amount of data is small or the data includes missing data, the statistical genetics analysis is performed with relatively high accuracy.