Implantable drug delivery devices

摘要

The invention relates generally to implantable drug delivery devices. Devices having a single drug chamber configuration, a divided drug chamber configuration and a compact dual-drug configuration are described. The devices have features to prevent clogging of the dispensing catheter and the creation of a local vacuum caused by the dispensing of the drug fluid. Also provided are features of a failsafe refilling process, automatic refill notification, and performance verification process. The divided drug chamber configuration enables frequent or continuous minute doses. A dual-drug chamber configuration uses self-locking refill containers to prevent mismatching between refill containers and drug chambers.

主权项

1. A refill container for refilling an implantable drug delivery device comprising:
a. a tubular housing with inner wall surface having first opening and second opening, said tubular housing containing a drug fluid, b. a needle being attached to the second opening, said needle being in flow communication with the tubular housing, c. a disc situated inside said tubular housing in slidable sealing fit with an inner wall surface, said disc not accessible from outside the housing and being only movable following the flow direction toward the needle when the drug fluid is being removed from the housing through the needle, said disc being exposed to ambient pressure through the first opening.