发明名称 |
Compounds for targeting drug delivery and enhancing siRNA activity |
摘要 |
Here described are compounds consisting of the structure
(targeting molecule)m-linker-(targeting molecule)n,
wherein the targeting molecule is a retinoid or a fat soluble vitamin having a specific receptor on the target cell; wherein m and n are independently 0, 1, 2 or 3; and wherein the linker comprises a polyethylene glycol (PEG) or PEG-like molecule, as well as compositions and pharmaceutical formulations including these compounds which are useful for the targeting and delivery of therapeutic agents; and methods of using these compositions and pharmaceutical formulations. |
申请公布号 |
US9393315(B2) |
申请公布日期 |
2016.07.19 |
申请号 |
US201213492424 |
申请日期 |
2012.06.08 |
申请人 |
Nitto Denko Corporation |
发明人 |
Niitsu Yoshiro;Payne Joseph E.;Gaudette John A.;Hou Zheng;Knopov Victor;Witte Richard P.;Ahmadian Mohammad;Perelman Loren A.;Tanaka Yasunobu;Akopian Violetta |
分类号 |
A61K9/127;C07C235/30;A61K31/166;A61K31/23;A61P1/16;A61P1/18;A61P11/04;C07F9/10;A61K31/685;A61K31/713;C07C229/32;C07C235/48;A61K47/48;C07C237/22;C07C235/08 |
主分类号 |
A61K9/127 |
代理机构 |
Baker & Hostetler LLP |
代理人 |
Baker & Hostetler LLP |
主权项 |
1. A compound, consisting of the structure (targeting molecule)m-linker-(targeting molecule)n, wherein the targeting molecule consists of a retinoid or a fat soluble vitamin having a specific receptor on the target cell; wherein m and n are independently 1, 2, or 3; wherein m+n=4-6; and wherein the linker comprises one or more elements selected from a polyethylene glycol (PEG), glutarate (Glu), hexyl, Gly3, and 4-aminobutanoate (GluNH). |
地址 |
Osaka JP |