TREATMENTS FOR FIBROTIC DISEASES

摘要

Disclosed herein are methods for treatment for fibrosis, ocular pathologies associated with fibrosis, including proliferative vitreoretinopathy (PVR) by inhibiting the activity of activated transforming growth factor β activated kinase 1 (TAK1), or activation thereof. Pharmaceutical compositions for use in the described treatments are also provided.

主权项

1. A method for treatment of fibrosis in a subject, comprising:
administering to a subject in need thereof, a therapeutically effective amount of an inhibitor of at least one of the activation or kinase activity of transforming growth factor β activated kinase 1 (TAK-1), thereby preventing or treating the fibrosis.