Pharmaceutical composition of hedgehog proteins and use thereof

摘要

A pharmaceutical composition of a hedgehog protein which is characterized in that the hedgehog protein is bound to a hydrophilic carrier that is biocompatible and biodegradable wherein the carrier is a polymer which binds the hedgehog protein as a negatively-charged carrier as a result of ionic interactions, does not denature the hedgehog protein when it binds to the carrier, contains at least 0.1 to 2 negatively-charged residues per monomer under neutral conditions, contains the charge in the form of acidic groups, has an average molecular weight of at least 50,000 Da and contains no agarose reversibly and actively releases hedgehog proteins in vivo from a carrier in a delayed manner.