| 发明名称 | IFNγR2 compositions and methods of inhibiting neuronal cell death | ||
| 摘要 | A method of inhibiting β-amyloid (Aβ) induced neuronal cell death includes administering to a neuronal cell exposed to a neurotoxic amount of Aβ a therapeutically effective amount of cell penetrating peptide (CPP). The CPP has an amino acid sequence that has at least 80% sequence identity to about 5 to about 41 consecutive amino acids of SEQ ID NO: 1. | ||
| 申请公布号 | US9458427(B2) | 申请公布日期 | 2016.10.04 |
| 申请号 | US201414279432 | 申请日期 | 2014.05.16 |
| 申请人 | Case Western Reserve University | 发明人 | Matsuyama Shigemi |
| 分类号 | A61K38/04;C07K14/715;C12N5/0793;A61K38/08;A61K38/07;C07K16/28 | 主分类号 | A61K38/04 |
| 代理机构 | Tarolli, Sundheim, Covell & Tummino LLP | 代理人 | Tarolli, Sundheim, Covell & Tummino LLP |
| 主权项 | 1. A method of inhibiting β-amyloid (Aβ) induced neuronal cell death, the method comprising: administering to a neuronal cell exposed to a neurotoxic amount of Aβ a therapeutically effective amount of cell penetrating peptide (CPP), the CPP consisting of 5 to about 41 consecutive amino acids of SEQ ID NO: 1, the CPP comprising PILEA (SEQ ID NO: 2), and the CPP binding to Bax in the cell and inhibiting Bax mediated apoptosis in the cell. | ||
| 地址 | Cleveland OH US | ||