Method of determining administration effect in cancer chemotherapy with S-1

摘要

Provided is a method of determining a therapeutic effect of cancer chemotherapy with an anticancer drug obtained by blending three ingredients, i.e., tegafur, gimeracil, and oteracil potassium as active ingredients (hereinafter abbreviated as S-1) quickly, simply, and accurately before carrying out the cancer chemotherapy. Specifically, provided is a method of determining an administration effect in chemotherapy with S-1, the method comprising: a step (a) of measuring expression level of a decorin gene in a biological sample collected from a subject to be diagnosed; and a step (b) of determining an administration effect of S-1 based on the expression level of the gene obtained from the measurement.

主权项

1. A method of administering chemotherapy with S-1 for a subject in need of chemotherapy, the method comprising:
a step (a) of collecting a biological sample from a subject before carrying out chemotherapy with S-1, wherein S-1 is obtained by blending tegafur, gimeracil, and oteracil potassium as active ingredients, the biological sample comprises a cancer tissue, and the biological sample is from a head and neck squamous cell carcinoma patient or an oral squamous cell carcinoma patient; a step (b) of measuring expression level of a decorin gene in the biological sample collected from the subject before carrying out the chemotherapy with S-1; a step (c) of predicting an administration effect of S-1 using a predetermined reference value wherein the subject is assessed to have resistance to S-1 when the expression level of the decorin gene in the biological sample is high as compared to the predetermined reference value, while the subject is assessed to have sensitivity to S-1 when the expression level of the decorin gene is low as compared to the predetermined reference value; a step (d) of identifying the subject as having the sensitivity to S-1; and a step (e) administering said chemotherapy with S-1 to the subject assessed to have the sensitivity to S-1.