| 发明名称 | Modified polymerases for replication of threose nucleic acids | ||
| 摘要 | Methods and compositions for replication of threose nucleic acids (TNAs) are described. The described methods include a method for transcribing a DNA template into a TNA, and a method for reverse transcribing a threose nucleic acid into a cDNA. | ||
| 申请公布号 | US9469862(B2) | 申请公布日期 | 2016.10.18 |
| 申请号 | US201514820072 | 申请日期 | 2015.08.06 |
| 申请人 | Arizona Board of Regents on Behalf of Arizona State University | 发明人 | Chaput John;Dunn Matthew |
| 分类号 | C12N9/12;C12P19/34;C12P7/34 | 主分类号 | C12N9/12 |
| 代理机构 | Quarles & Brady LLP | 代理人 | Quarles & Brady LLP |
| 主权项 | 1. A purified threose nucleic acid (TNA) polymerase comprising an amino acid sequence at least 95% identical to SEQ ID NO:1, wherein, the residue corresponding to 141 of SEQ ID NO:1 is an alanine, residue 143 is an alanine, residue 485 is an arginine, and residue 664 is an isoleucine; and wherein the encoded DNA polymerase synthesizes a TNA in the presence of a DNA template and threose nucleotides. | ||
| 地址 | Scottsdale AZ US | ||