GANESIN, AN 18-RESIDUE CYSTEINE-RICH DEFENSE PEPTIDE FROM SPIDER AND RELATED ANTINICROBIAL PAPDIDES, THEIR PREPARATION AND USES.

摘要

The invention refers to small peptides with low hemolytic activity, presenting equal antiparasitic, antifungal and antibacterial activities. More specifically, it refers to a peptide called gomesin, with 18 amino acid residues, configured as a clamp-like structure consisting of two anti-parallel beta-folded sheets joined by a beta turn, containing four invariable residues of cystein forming two disulphide bridges, optionally configurable as a cyclic chain with closed edges.