| 主权项 |
1. A method for treating pulmonary vasoconstriction in a patient, comprising:
a) providing a nasal cannula assembly (10) adapted to deliver gases to the patient, the nasal cannula assembly (10) comprising:
A) a hollow body (4) configured to be capable of acting as a gas conduct or a gas manifold and comprising an internal chamber (7) defining a first compartment (1),B) the first compartment (1) and a second compartment (2) separated by a separation wall (6),C) a pair of nasal prongs (5) in fluid communication with the first compartment (1),D) the first compartment (1) comprising a first inlet (11) forming a side gases entry in fluid communication with a gas transport conduct and configured to conduct a first gas into said first compartment (1),E) the second compartment (2) having a fully inflated internal volume for a gas of about 0.5 to 5 ml, the second compartment (2) comprising,
a second inlet (12) configured to conduct a second gas into said second compartment (2), anda deformable wall (14) having a greater compliance while filling than when the second compartment (2) is full,F) the separation wall (6) comprising two, one-way, duckbill or umbrella valves (3) a cracking pressure of 0.5 kPa or less which are oriented and arranged in the separation wall (6) directly opposite the pair of nasal prongs (5) to thereby be capable of
permitting a passage of gas from the second compartment (2) to the first compartment (1) andpreventing or limiting a passage of gas from the first compartment (1) to the second compartment (2), b) providing a source of NO-containing gas having from 1 ppm to 5000 ppm in volume of NO in a balance of nitrogen in fluid communication with the nasal cannula assembly (10), c) providing a source of an oxygen-containing gas containing at least 21% (by volume) of O2 in fluid communication with the nasal cannula assembly (10), and d) providing a therapeutically-effective amount of the NO-containing gas to said patient through said nasal cannula assembly for inhalation. |
