Berban derivatives as alpha 2-adrenergic antagonists

摘要

The invention relates to novel racemic or optically active berban derivatives of the formula (I) <IMAGE> (I) wherein R1 and R2 represent independently from the other a hydroxyl, straight or branched chain alkoxy group 1 to 6 carbon atoms or R1 and R2 together represent a C1-3 alkylenedioxy group; R3 and R4 represent independently from the other hydrogen, straight or branched chain alkyl group, having 1 to 6 carbon atoms and optionally substituted by hydroxyl group, or a C2-6 alkoxycarbonyl or cyano group; and R5 represents hydrogen, straight or branched chain alkyl group having 1 to 6 carbon atoms, C1-7 aliphatic or aromatic acyl group or C1-7 alkylsulphonyl or arylsulphonyl group, and a salt thereof, to pharmaceutical compositions containing them, to the use as well as to process for preparing the novel compounds. The compounds of the formula (I) are selective alpha 2-adrenergic receptor-blocking substances and thus, they may be used for the treament of depressive illnesses.