A human prostatic specific reductase polypeptide and polynucleotides encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides as a diagnostic marker for prostate cancer and as an agent to determine if the prostate cancer has metastasized. Also disclosed are antibodies specific to the prostatic specific reductase polypeptide which may be used to target prostate cancer cells and be used as part of a prostate cancer vaccine. Methods of screening for agonists and antagonists for the polypeptide and therapeutic uses of the antagonists are also dislcosed.
申请公布号
WO9622360(A1)
申请公布日期
1996.07.25
申请号
WO1995US01827
申请日期
1995.01.20
申请人
HUMAN GENOME SCIENCES, INC.;HE, WEI, WU;MEISSNER, PAUL, S.;HUDSON, PETER, L.;ROSEN, CRAIG, A.
发明人
HE, WEI, WU;MEISSNER, PAUL, S.;HUDSON, PETER, L.;ROSEN, CRAIG, A.