MAMMALIAN ADDITIONAL SEX COMBS (MAMMALIAN Asx) ACTS AS AN ONCOGENE

摘要

Mammalian Asx gene and amino acid sequences encoded by the mammalian Asx gene, are described. The mammalian Asx gene and gene products are useful for diagnostic and therapeutic applications in proliferative and developmental disorders. Modulators of mammalian Asx can be identified using the disclosed genes. The modulators can be used in the context of cancer therapy or a treatment of a developmental disorder. Asx is also useful for inducing de-differentiation in a population of differentiated cells.