| 摘要 |
The present invention provides VSV vectors comprising nucleic acid encoding a HTLV-1 viral protein, such as HTLV-1 gag and env proteins, from any strain of HTLV-1 for the production of HTLV-1 VLPs. The present invention provides VSV vectors comprising nucleic acid encoding a HPV viral protein, such as HPV L1 or L1 and L2, from any strain of HPV for the production of HPV VLPs. The present invention also provides methods of making such vectors, host cells, expression systems, and compositions comprising such VSV vectors, and viral particles comprising such VSV vectors. The present invention also provides vaccine compositions and provides methods for eliciting an immune response in an individual and methods for ameliorating symptoms of disease.
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