发明名称 |
NYE INSULINDERIVATER MED EKSTREMT FORSINKET TIDS-/VIRKNINGSPROFIL |
摘要 |
The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the following features: a) the B chain end consists of an amidated basic amino acid residue such as lysine or arginine amide; b) the N-terminal amino acid residue of the insulin A chain is a lysine or arginine radical; c) the amino acid position A8 is occupied by a histidine radical; d) the amino acid position A21 is occupied by a glycine radical; and e) one or more substitutions and/or additions of negatively charged amino acid residues are carried out in the positions A5, A15, A18, B-1, B0, B1, B2, B3 and B4. |
申请公布号 |
DK2229407(T3) |
申请公布日期 |
2017.02.27 |
申请号 |
DK20090701358T |
申请日期 |
2009.01.06 |
申请人 |
Sanofi-Aventis Deutschland GmbH |
发明人 |
HABERMANN,Paul;SEIPKE, Gerhard;KURRLE, Roland;MÜLLER, Günter;SOMMERFELD, Mark;TENNAGELS, Norbert;TSCHANK, Georg;WERNER, Ulrich |
分类号 |
C07K14/62 |
主分类号 |
C07K14/62 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|