| 发明名称 |
MULTIEPITOPE FUSION ANTIGENS AND VACCINES AND THEIR USE IN TREATMENT OF ENTEROTOXIGENIC DIARRHEA |
| 摘要 |
Provided herein are polypeptides comprising up to 9 antigenic elements of ETEC virulence determinants: 7 CFA adhesins [CFA/I, CFA/II (CS1, CS2, CS3), CFA/IV (CS4, CS5, CS6)] expressed by the most prevalent and virulent ETEC strains, and 2 toxins expressed by all ETEC strains, were genetically fused together for CFA-toxoid fusion with proteins (CFA/I/II/IV-STa-toxoidLTtoxoid). Methods for making these polypeptides and their use in the treatment of ETEC related disease are also provided. |
| 申请公布号 |
US2016317638(A1) |
申请公布日期 |
2016.11.03 |
| 申请号 |
US201415105195 |
申请日期 |
2014.12.17 |
| 申请人 |
THE JOHNS HOPKINS UNIVERSITY ;SOUTH DAKOTA STATE UNIVERSITY |
发明人 |
Sack David A.;Zhang Weiping |
| 分类号 |
A61K39/108;A61K45/06;A61K39/08;C07K14/245 |
主分类号 |
A61K39/108 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A fusion polypeptide molecule comprising the colonization factor antigens (CFA) antigens CFA/I, CFA/II (CS1, CS2, CS3), CFA/IV (CS4, CS5, CS6). |
| 地址 |
Baltimore MD US |
