发明名称 |
Hsp70 modulators and methods for making and using the same |
摘要 |
The present invention provides compounds I and II and compositions thereof for use in the modulation of Hsp70. In some embodiments, the present invention provides a method for inhibiting Hsp70 activity. In some embodiments, the present invention provides a method of treating a subject suffering from or susceptible to a disease, disorder, or condition responsive to Hsp70 inhibition comprising administering to the subject a therapeutically effective amount of a provided compound. In some embodiments, the present invention provides a method for treating or preventing cancer in a subject suffering therefrom, comprising administering to a patient in need thereof a therapeutically effective amount of a provided compound. |
申请公布号 |
AU2015259173(A1) |
申请公布日期 |
2016.12.08 |
申请号 |
AU20150259173 |
申请日期 |
2015.05.13 |
申请人 |
Memorial Sloan Kettering Cancer Center |
发明人 |
Chiosis, Gabriela;Kang, Yanlong;Patel, Hardik J.;Patel, Maulik;Ochiana, Stefan;Rodina, Anna;Taldone, Tony;Shrestha, Liza |
分类号 |
C07D401/12;A61K31/505;A61P35/00;C07D239/42;C07D413/12 |
主分类号 |
C07D401/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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