PREDICTING MORBIDITY ASSOCIATED WITH RED BLOOD CELL VOLUME VARIANCE

摘要

A method for evaluating a risk of a morbidity associated with elevated red blood cell (RBC) volume variation (RDW) includes measuring, using a hematology analyzer, a complete blood count (CBC) of a blood sample including a population of RBCs from a subject. In some embodiments, the method includes estimating a normalized clearance volume of the population of the RBCs based on the CBC. In some embodiments, the method includes comparing the normalized clearance volume to a reference value. In some embodiments, the method includes determining a risk level for the patient to develop the morbidity associated with elevated RDW within a specified time period. In some embodiments, the risk level is high if the normalized clearance volume is below the reference value, and the risk level is low if the normalized clearance volume is above the reference value. In some embodiments, the method further includes selecting the patient for diagnostic workup for the morbidity if the risk level is high. In some embodiments, the morbidity is not anemia.

主权项

1. A method for evaluating a risk of a morbidity associated with elevated red blood cell (RBC) volume variation (RDW):
measuring, using a hematology analyzer, a complete blood count (CBC) of a blood sample comprising a population of RBCs from a subject; estimating a normalized clearance volume of the population of the RBCs based on the CBC, the normalized clearance volume being indicative of a volume below which clearance occurs for most of the population of RBCs; comparing the normalized clearance volume to a reference value; determining a risk level for the subject to develop the morbidity associated with elevated RDW within a specified time period, wherein the risk level is high if the normalized clearance volume is below the reference value, and the risk level is low if the normalized clearance volume is above the reference value; and selecting the subject for diagnostic workup for the morbidity if the risk level is high, wherein the morbidity is not anemia.