发明名称 |
Methods for treating cone dystrophy with neuronal viability factor, RDCVF2 |
摘要 |
The present disclosure concerns a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound selected in the group comprising (i) a polypeptide comprising an amino acid sequence selected in the group comprising the amino acid sequence of the long isoform in Homo sapiens of the RdCVF2 gene (SEQ ID NO:10), orthologs, derivatives and fragments thereof, (ii) a polynucleotide coding for said polypeptide, (iii) a vector comprising said polynucleotide, and (iv) a host cell genetically engineered expressing said polypeptide; the use of such a composition for the manufacture of a medicament for treating and/or preventing a neurodegenerative disorder in a subject; and a method of testing a subject thought to have or be predisposed to having a neurodegenerative disorder. |
申请公布号 |
US9575075(B2) |
申请公布日期 |
2017.02.21 |
申请号 |
US200812602736 |
申请日期 |
2008.06.05 |
申请人 |
INSERM (Institut National de la Sante et Recherche Medicale);Centre National de la Recherche Scientifique (CNRS) |
发明人 |
Leveillard Thierry;Sahel José-Alain;Jaillard Céline;Poch Olivier |
分类号 |
A61K38/00;A61K49/00;A61K38/18;C07K14/475;C07K14/48;C07K14/00;A61K38/16;G01N33/68;A61K38/44;C07K14/435 |
主分类号 |
A61K38/00 |
代理机构 |
Whitham, Curtis & Cook, P.C. |
代理人 |
Whitham, Curtis & Cook, P.C. |
主权项 |
1. A method for treating cone dystrophy comprising the administration of an effective amount of a polypeptide comprising the amino acid sequence of long isoform in Homo sapiens of the RdCVF2 gene, and having the sequence set forth in SEQ ID NO:10, to a patient in need thereof. |
地址 |
Paris FR |