The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.
申请公布号
EP3122353(A1)
申请公布日期
2017.02.01
申请号
EP20150768818
申请日期
2015.03.26
申请人
Vanderbilt University
发明人
LEE, Taekyu;BIAN, Zhiguo;BELMAR, Johannes;CHRISTOV, Plamen P.;PELZ, Nicholas F.;SHAW, Subrata;KIM, Kwangho;TARR, James C.;OLEJNICZAK, Edward T.;ZHAO, Bin;FESIK, Stephen W.
