| 发明名称 |
ANTI-TRANSTHYRETIN ANTIBODIES |
| 摘要 |
The invention provides antibodies that specifically bind to transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing aggregation of TTR, among other applications. |
| 申请公布号 |
US2017015737(A1) |
申请公布日期 |
2017.01.19 |
| 申请号 |
US201615201429 |
申请日期 |
2016.07.02 |
| 申请人 |
PROTHENA BIOSCIENCES LIMITED ;UNIVERSITY HEALTH NETWORK |
发明人 |
Nijjar Tarlochan S.;Chakrabartty Avijit;Higaki Jeffrey N. |
| 分类号 |
C07K16/18;G01N33/68;A61K49/00 |
主分类号 |
C07K16/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An antibody that specifically binds transthyretin comprising three heavy chain CDRs and three light chain CDRs substantially from antibody 5A1. |
| 地址 |
Dublin IE |
