发明名称 |
Method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)-prop-2-en-1-one hydrochloride and intermediates used therein |
摘要 |
The present invention relates to an improved method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)-prop-2-en-1-one hydrochloride, which selectively and effectively inhibits the growth of cancer cells induced by over-expression of an epidermal growth factor receptor (EGFR) and prevents the development of drug resistance caused by mutation of a tyrosine kinase, and intermediates used therein. |
申请公布号 |
AU2012319291(B2) |
申请公布日期 |
2016.03.31 |
申请号 |
AU20120319291 |
申请日期 |
2012.10.05 |
申请人 |
HANMI SCIENCE CO., LTD. |
发明人 |
BANG, KEUK CHAN;MOON, YOUNG HO;CHANG, YOUNG KIL |
分类号 |
C07D401/12;A61K31/517 |
主分类号 |
C07D401/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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