| 摘要 |
PROBLEM TO BE SOLVED: To provide a composition comprising rotigotine or a pharmaceutically acceptable salt thereof used for treating Parkinson's disease, having a greatly reduced burst release effect.SOLUTION: The invention relates to a composition containing about 20-40% of rotigotine or a pharmaceutically acceptable salt thereof; about 57.5-72.5% of at least one poly (lactide-co-glycolide) having a molecular weight of about 5000-100000 Da; and about 2.5-7.5% of at least one fatty acid having 8-24 carbon atoms. The pharmaceutically acceptable salt is a salt formed with an inorganic acid comprising hydrochloric acid, sulphuric acid, phosphoric acid, and nitric acid, or an organic acid comprising citric acid, fumaric acid, maleic acid, acetic acid, benzoic acid, lactic acid, methanesulfonic acid, or toluenesulfonic acid, or an acidic amino acid such as glutamic acid or aspartic acid.SELECTED DRAWING: None |
